ISCB iRNA COSI and RNA Society present
Dynamic Determinants of Co-transcriptional Gene Regulation
Presented by Ana Fiszbein, Massachusetts Institute of Technology
Plan to Watch!
Join us April 21, 2020 at 11am EDT for this jointly hosted webinar. ISCBacademy is complimenatry for all ISCB members. In partnership with the RNA Society, we are also offering this content complimentary to RNA Society members. Not a Member? You can still join for a nominal fee OR become a member and get this webinar and upcoming ones free!
The architecture of mammalian genes enables the production of multiple transcripts that greatly expand the coding capacity of our genomes. Understanding how these transcripts are regulated is of particular importance in cancer genomics, as their aberrant regulation contributes to the ~10 million cancer-related deaths each year. We recently described a phenomenon called exon-mediated activation of transcription starts (EMATS) in which the splicing of internal exons impacts the spectrum of promoters used and expression level of the host gene. We showed that targeted-inhibition of splicing reduces the usage of promoters and suppresses gene expression, while evolutionary creation of a new splice site can activate cryptic promoters. My findings support a model in which splicing factors recruit transcription machinery to influence promoter choice and regulate the expression of thousands of mammalian genes.